Revised guidelines for the welfare and use of animals in cancer research have been published in the British Journal of Cancer, developed by a committee established by the UK’s National Cancer Research Institute (NCRI). The previous guidelines are cited in innumerable US research animal care policies.
It is clearly important that the welfare of animals in cancer research is protected, both from an ethical point of view and also because it is widely acknowledged to be entirely consistent with good science (Osborne et al, 2009). Under the earlier sponsorship of the former United Kingdom Coordinating Committee for Cancer Research (UKCCCR), two sets of guidelines have been published previously (Workman, 1988; Workman et al, 1998). Although these guidelines were well received, and are still widely used and cited, it is over 10 years since they were last revised, in which time the science has moved on appreciably. The main aim of this article is to provide new guidelines for the cancer research community concerning the use of experimental animals in oncology, with a major emphasis on their welfare. We focus on rodents as these are predominantly used for cancer research…
Workman P, Aboagye EO, Balkwill F, Balmain A, Bruder G, Chaplin DJ, Double JA, Everitt J, Farningham DAH, Glennie MJ, Kelland LR, Robinson V, Stratford IJ, Tozer GM, Watson S, Wedge SR, Eccles S, An ad hoc committee of the National Cancer Research Institute
Guidelines for the welfare and use of animals in cancer research
British Journal of Cancer (2010) 102, 1555–1577 BJC Open
Animal experiments remain essential to understand the fundamental mechanisms underpinning malignancy and to discover improved methods to prevent, diagnose and treat cancer. Excellent standards of animal care are fully consistent with the conduct of high quality cancer research. Here we provide updated guidelines on the welfare and use of animals in cancer research. All experiments should incorporate the 3Rs: replacement, reduction and refinement. Focusing on animal welfare, we present recommendations on all aspects of cancer research, including: study design, statistics and pilot studies; choice of tumour models (e.g., genetically engineered, orthotopic and metastatic); therapy (including drugs and radiation); imaging (covering techniques, anaesthesia and restraint); humane endpoints (including tumour burden and site); and publication of best practice.
Guidelines publication history:
UK Co-ordinating Committee on Cancer Research
UKCCCR guidelines for the welfare of animals in experimental neoplasia
Laboratory Animals (1988) 22, 195-201 RSM reprint
Cancer and Metastasis Reviews 8: 82-88, 1989 SpringerLink
UKCCCR Guidelines for the Welfare of Animals in Experimental Neoplasia (2nd ed.) 1997 NCRN reprint