Department Blog

Health Sciences Libraries

Alternative Methods: ALTEX, AltTox, Altweb

April 30th, 2013 by Mary Wood

Excerpted from the April/May 2013 AltTox Digest

A Field Guide to the Alts

ALTEX Alternatives to Animal Experimentation, is a peer-reviewed scientific journal featuring research and commentary on the development of alternatives to animal experimentation.  Produced by the Center for Alternatives to Animal Testing (CAAT) at Johns Hopkins University, ALTEX is the “official journal” of CAAT, the European Society for Alternatives to Animal Testing (EUSAAT), and the Transatlantic Think Tank of Toxicology (t4).

Altweb is CAAT’s website for news, notices of meetings and events, information on alternative methods for biomedical research, testing, and education. Altweb includes such features as a step-by-step guide to searching for alternative methods, links to external literature databases, links to international policies and regulations on the use of animals in research, and tutorials and information on replacement, refinement, and reduction.

AltTox is a website devoted exclusively to promoting the development, validation, and acceptance of non-animal toxicity testing methods. Its focus is limited primarily to replacement and one area of animal use toxiciology. Other resources include extensive information on international programs and policies, and a unique Table of Validated and Accepted Alternative Methods that covers methods reviewed by ICCVAM, ECVAM, and JaCVAM.

UC Davis Center for Animal Alternatives Information

Happy National DNA Day!

April 25th, 2013 by Amy Studer

DNA Tower

April 25, 2013 is National DNA Day, commemorating:

  1. completion of the Human Genome Project in April 2003, and
  2. discovery of the double helix of DNA in 1953.

You may wish to celebrate the day by playing with a few molecules.  Here is one tool to explore:

Molecules free app for iOS:

Molecules allows you to view and manipulate three-dimensional renderings of molecules.  You can search the PubChem and RCSB Protein Data Bank for interesting molecules and download them onto your iOS device.

Image credit:  DNA Tower by Steven2358

Predicting Emerging Diseases

April 23rd, 2013 by Mary Wood

Which Primate is the Most Likely Source of the Next Pandemic?
Smithsonian Surprising Science Blog April 22, 2013

photo by AfrikaForce

photo by AfrikaForce

“…Most emerging infectious diseases in humans have indeed arisen from animals… Therefore, experts prioritize the task of figuring out which animals in which regions of the world are most prone to delivering the latest novel pathogen to hapless humanity.

With this in mind, researchers at Harvard University, the University of Granada and the University of Valencia set out to develop a new strategy for predicting the risk and rise of new diseases transmitted from animals before they happen, describing their efforts in the journal Proceedings of the National Academy of Sciences, Centrality in primate–parasite networks reveals the potential for the transmission of emerging infectious diseases to humans
doi: 10.1073/pnas.1220716110 PNAS April 22, 2013
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School of Veterinary Medicine | One Health Institute |
PREDICT
:  Building global surveillance to detect and prevent spillover of pathogens of pandemic potential

USAID PREDICT Summary

.Morse SS, Mazet JA, Woolhouse M, Parrish CR, Carroll D, Karesh WB, Zambrana-Torrelio C, Lipkin WI, Daszak P.
Prediction and prevention of the next pandemic zoonosis
Lancet 2012 Dec 1;380(9857):1956-65 PMID: 23200504

“…In order to predict, respond to, and prevent the emergence of novel infectious diseases in humans, pathogens must be identified at their source. The PREDICT project, led by Principal Investigator and Co-Director Dr. Jonna A.K. Mazet, DVM, MVPM, PhD of the UC Davis School of Veterinary Medicine and Co-Director Stephen S. Morse, PhD of the Columbia University Mailman School of Public Health, recognizes that explosive human population growth and environmental changes have resulted in increased numbers of people living in close contact with animals.

PREDICT, a project of USAID’s Emerging Pandemic Threats Program, is building a global early warning system to detect and reduce the impacts of emerging diseases that move between wildlife and people (zoonotic diseases)…”

JoVE – Journal of Visualized Experiments

April 22nd, 2013 by Bruce Abbott

The Library has subscribed to all the parts of JoVE, so all content is now available. The URL for JoVE is:
http://www.jove.com/

24th Annual Undergraduate Research, Scholarship, & Creative Activities Conference

April 17th, 2013 by Ferguson Mitchell

UC Davis undergraduates in all academic fields are invited to submit an abstract and registration information to participate in the Undergraduate Research, Scholarship and Creative Activities Conference. Research projects must have been conducted under the supervision of a faculty member or professional in the field. The conference is designed to acquaint undergraduates with the process and academic rigors of presenting research in a scholarly manner.

Additionally, the conference will stimulate interaction between students and faculty, while encouraging undergraduates to pursue advanced degrees toward the goal of research and college teaching.Student poster presenter

Poster Presentations • Friday, April 26, 2013 • Freeborn Hall • 3:00 – 6:00 p.m.

Arts Exhibit • Friday, April 26, 2013 • Memorial Union II • 6:00 – 7:00 p.m.

Oral Presentations • Saturday, April 27, 2013 • Wellman Hall • 1:00 – 6:00 p.m.

Students will present their research projects to faculty, staff and other conference participants in either an oral or poster format. The oral presentation will allow students to give a 15-minute presentation of their topic and includes time for questions. Each oral session will be moderated by a faculty member. In the poster session, students will have designed a visual poster representing their research and will be presenting their work to individual conference participants over a 1-hour session.

While participating in research provides excellent preparation for graduate study, presenting your work at this conference will further enhance your experience and become even more valuable as you are considered for admission to graduate or professional schools. Each student selected to be a presenter will be individually recognized for his/her contribution to university academic achievement.

The Undergraduate Research, Scholarship & Creative Activities Conference is organized by a campus-wide committee and chaired by Tammy Hoyer, Undergraduate Research Center. The conference is sponsored by the Office of the Provost and the Office of the Vice Chancellor for Student Affairs.

Image courtesy NWABR via Flickr.

Open Access Theses and Dissertations

April 9th, 2013 by Mary Wood

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OATD currently indexes over 1.5 million open access international graduate theses and dissertations

Metadata from over 600 colleges, universities, and research institutions.

OATD FAQ

Many of these schools’ records come from their own repositories. Others come from regional or national ETD consortia, or from a set of ETD catalog records provided by OCLC Worldcat. With few exceptions, records are harvested from these sites using a standard called the Open Archives Initiative Protocol for Metadata Harvesting (OAI-PMH).

Additional resources to find theses:

    Proquest Dissertations and Theses, dissertations and theses published electronically or in print.

    Google Scholar

    NDLTD, Networked Digital Library of Theses and Dissertations, electronic theses and dissertations, both open access and not.

    IOM Workshop Summaries Released

    April 3rd, 2013 by Mary Wood

    Cognitive Rehabilitation Therapy for Traumatic Brain Injury: Model Study Protocols and Frameworks to Advance the State of the Science: Workshop Summary
    Karin Matchett, Rapporteur; Board on the Health of Select Populations; Institute of Medicine

    In October 2011, the Institute of Medicine (IOM) released the report Cognitive Rehabilitation Therapy for Traumatic Brain Injury: Evaluating the Evidence, assessing the published evidence for the effectiveness of using cognitive rehabilitation therapy (CRT) to treat people with traumatic brain injury (TBI). The Department of Defense (DoD) asked the IOM to evaluate CRT for traumatic brain injury in order to guide the DoD’s use and coverage in the Military Health System.

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    Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary
    Diana E. Pankevich, Theresa M. Wizemann, and Bruce M. Altevogt, Rapporteurs; Board on Health Sciences Policy; Institute of Medicine

    On March 28 and 29, 2012, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened the workshop “Improving Translation of Animal Models for Nervous System Disorders” to discuss potential opportunities for maximizing the translation of new therapies from animal models to clinical practice. The primary focus of the workshop was to examine mechanisms for increasing the efficiency of translational neuroscience research through discussions about how and when to use animal models most effectively and then best approaches for the interpretation of the data collected.

    New NIH funding for two Autism Centers of Excellence

    April 2nd, 2013 by Mary Wood

    A total of 11 centers now funded for up to five years

    The National Institutes of Health has awarded $5.3 million in initial one-year funding to the latest two recipients of the Autism Centers of Excellence (ACE) program. With these awards, announced on World Autism Awareness Day, these and nine other ACE centers around the country are now being funded for up to five years. The program was created in 2007 to launch an intense and coordinated research effort aimed at identifying the causes of autism spectrum disorders (ASD) and finding new treatments.

    The new ACE awards will fund two research networks:

    • Sally J. Rogers, Ph.D., University of California, Davis MIND Institute. The UC Davis network will conduct multi-site randomized clinical trials to provide information on what effects the style of early intervention for young children with autism, and the intensity of treatment, have on children’s development.  A second study aims to determine whether toddlers who received early intervention in a previous clinical trial show long-term benefits from the intervention.  Centers participating with UC Davis are the McLean Hospital, Belmont, Mass.; the University of Washington, Seattle; and Vanderbilt University, Nashville
    • Daniel Geschwind, M.D., Ph.D., University of California, Los Angeles. The UCLA ACE will build on the network’s earlier work identifying genetic variants associated with autism susceptibility, with an important new emphasis: the network aims to recruit at least 600 African-American families with a child with an ASD.  The work will also include an evaluation of disparities in diagnosis and access to care. Scientists at the Albert Einstein College of Medicine in New York City; Emory University, Atlanta; Johns Hopkins University, Baltimore; Washington University, St. Louis; and Yale University, New Haven, Conn., will carry out this study with UCLA.