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Research: increasing value, reducing waste

January 29th, 2014 by Mary Wood


Clinical Series
January 8, 2014

Executive summary

The Lancet presents a Series of five papers about research… These papers set out some of the most pressing issues, recommend how to increase value and reduce waste in biomedical research, and propose metrics for stakeholders to monitor the implementation of these recommendations.


Clinical Series
The Lancet commissions Series and themed issues to highlight clinically important topics and areas of health and medicine that are pertinent to physicians’ practice. They are groups of two or three articles which provide an in depth view of individual clinical areas, and are an ideal source of up-to-date knowledge.

NIH plans to enhance reproducibility

January 27th, 2014 by Mary Wood
27 January 2014

“Francis S. Collins and Lawrence A. Tabak discuss initiatives that the US National Institutes of Health is exploring to restore the self-correcting nature of preclinical research.”
Nature 505, 612–613 (30 January 2014) doi:10.1038/505612a



Nature | Special

Challenges in irreproducible research

“…Nature has published a series of articles about the worrying extent to which research results have been found wanting…  Journals, research laboratories and institutions and funders all have an interest in tackling issues of irreproducibility. We hope that the articles contained in this collection will help.”

Reporting animal studies: ARRIVE news

January 24th, 2014 by Mary Wood
Open Science and Report Animal Studies: Who’s Accountable?
Jonathan A. Eisen, Emma Ganley, Catriona J. MacCallum
(2014) PLoS Biol 12(1): e1001757. doi:10.1371/journal.pbio.1001757
Two Years Later: Journals Are Not Yet Enforcing the ARRIVE Guidelines on Reporting Standards for Pre-Clinical Animal Studies
Baker D, Lidster K, Sottomayor A, Amor S
(2014) PLoS Biol 12(1): e1001756. doi:10.1371/journal.pbio.1001756

from NC3Rs Blog
…The ARRIVE (Animal Research: Reporting of In Vivo Research) guidelines, published in 2010 in PLOS Biology, were developed … to improve the reporting of animal research to ensure maximum benefit and to minimise unnecessary animal studies…

Research published this week in PLOS Biology shows experimental flaws and inadequacies in the reporting of animal research in the field of neuroimmunology …

PLOS Biology published an editorial to coincide with the original article
PLOS journals are requesting authors to use the ARRIVE guidelines checklist when submitting relevant manuscripts to ensure reporting of animal research meets minimum standards. In April 2013, Nature journals adopted a similar approach and introduced editorial measures to improve transparency of research which includes a checklist incorporating elements of the ARRIVE guidelines…
Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research
Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG
(2010) PLoS Biol 8(6): e1000412. doi:10.1371/journal.pbio.1000412