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New MOU Among NIH, USDA, and FDA

June 7th, 2016 by Mary Wood

Office of Laboratory Animal Welfare – MOU Among USDA/FDA/NIH

NIH, USDA, and FDA have participated under a Memorandum of Understanding (MOU) Concerning Laboratory Animal Welfare for over 30 years. Each agency, operating under its own authority, has specific responsibilities for fostering proper animal care and welfare. This agreement sets forth a framework for reciprocal cooperation intended to enhance agency effectiveness while avoiding duplication of efforts in achieving required standards for the care and use of laboratory animals.

The new MOU is available at: http://grants.nih.gov/grants/olaw/references/finalmou.htm.

This follows the earlier, similar MOU between NIH and NSF
(blog post)

Animal welfare MOU between NIH and NSF

August 12th, 2015 by Mary Wood

Notice of Memorandum of Understanding Between NIH and NSF Concerning Laboratory Animal Welfare
Notice Number: NOT-OD-15-139

Memorandum of Understanding
NIH and NSF operate under a MOU to ensure consistent and effective oversight of the welfare of animals used in activities funded by the NSF. The agreement provides a framework to enhance communication and harmonize the agencies’ efforts while reducing regulatory burden to supported institutions. nsf_logoEffective October 1, 2015, institutions receiving NSF support must:

include NSF-supported activities with live vertebrate animals as covered activities in their OLAW Animal Welfare Assurance;
promptly report situations involving NSF-supported animal activities to OLAW as required by the Public Health Service (PHS) Policy on Humane Care and Use of Laboratory Animals, Section IV.F.3.
.banner-nihlogoOLAW will:

negotiate new Assurances for institutions with pending NSF awards;
review and evaluate noncompliance reports and the actions taken involving NSF-supported activities; and
report findings to NSF.

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Background
OLAW is responsible for administration and implementation of the PHS Policy. The Policy requires institutions to establish and maintain proper measures to ensure the appropriate care and use of all animals involved in research, research training, and biological testing activities. Institutions receiving PHS funding through grants, contracts or cooperative agreements for research involving vertebrate animals are required to comply with the PHS Policy.

NSF holds its awardees responsible for the humane care and treatment of any vertebrate animal used or intended for use in such activities as field or laboratory research, development, training, experiments, biological testing or for related purposes supported by NSF grants, contracts or cooperative agreements. Any NSF awardee performing research on vertebrate animals must comply with the Animal Welfare Act (AWA) [7 U.S.C. 2131 et seq.], the AWA regulations [9 CFR 1.1-4.11], the PHS Policy, and the U.S. Government Principles for the Utilization and Care of Vertebrate Animals Used in Testing, Research, and Training. The awardee must follow the guidelines described in the Guide for the Care and Use of Laboratory Animals and the AVMA Guidelines for the Euthanasia of Animals.

USDA Petitions: Definition of Alternatives & Establish Standards

April 1st, 2015 by Mary Wood

aphis.
USDA requests comment on a petition to

Define Alternatives to Procedures That May Cause Pain or Distress and
to Establish Standards Regarding Consideration of These Alternatives

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This Proposed Rule document was issued by the Animal and Plant Health Inspection Service (APHIS)

For related information, Open Docket Folder


Summary
APHIS has received a petition requesting amendment of the Animal Welfare Act (AWA) regulations to define the term alternatives, clarify the existing definition of painful procedure, and establish standards governing the consideration of such alternatives at research facilities that are registered under the AWA regulations. This petition is available to the public and they are soliciting comments regarding the petition and any issues raised by the petition that should be taken into account.

Dates
Comments due on or before May 29, 2015.

Submit comments online or as noted.

Supplementary information

AVMA Animal Welfare Symposium

October 8th, 2014 by Mary Wood

HumaneEndings_logo

AVMA Animal Welfare Symposium 2014

Humane endings :
In search of best practices for the euthanasia, humane slaughter and depopulation of animals

November 3-5, 2014
Westin O’Hare Chicago

The symposium will bring together thought leaders from around the globe to take a comprehensive look at existing best practices for euthanasia, humane slaughter and depopulation-across applicable species-while also providing access to new research with an aim toward continuous improvement.

Information gathered at the symposium will assist the AVMA in keeping its recommendations for humane endings for animals current. Attendees are expected to include representatives from research, clinical practice and public policy.

Symposium Agenda

Social Housing of Laboratory Animals: Symposium

September 8th, 2014 by Mary Wood

c7d7fa62-878d-4e29-b31d-a356816fcdecOctober 5-6, 2014
University of Colorado Anschutz Medical Campus
Sponsored by CAAT, Office of Laboratory Animal Welfare (NIH), APHIS and AWIC (USDA), and University of Colorado, Denver

This symposium, which is being held on the University of Colorado Anschultz Medical campus, will bring together experts in animal behavior and welfare to address common issues in trying to achieve the mandate for social housing for social species. The first day will focus on nonhuman primates and the second on ruminants, rabbits, rodents and pigs. Participants will be encouraged to discuss special issues they are facing at their institutions.

Full Details and Preliminary Agenda

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Reproducibility in Research with Animal Models

May 21st, 2014 by Mary Wood

The first workshop organized by the National Academies ILAR, Roundtable on Science and Welfare in Laboratory Animal Use will be held June 4-5, 2014 in Washington DC, and will discuss reproducibility issues in research with animals and animal models.

Reproducibility Issues in Research with Animals and Animal Models: A Workshop

June 4-5, 2014
Register here to join in person or by webcast

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Workshop Agenda
Restoring Faith in the Research Enterprise: A Call to Action
Malcolm Macleod, Univ of Edinburgh ;  Henry Bourne, Univ of California San Francisco

Citizens and Science: How Reproducibility Directly Impacts Public Perceptions
Robert Bazell, Yale Univ ; Jan Piotrowski, The Economist

Great Expectations – Critical Assessment of Published Research
C. Glenn Begley, TetraLogic Pharmaceuticals

Heard but Not Learned? Impact and Outcomes of Previous ILAR Efforts
Jeffrey Everitt, GlaxoSmithKline ;  Coenraad F. M. Hendriksen, Netherlands Vaccine Institute

All Hands on Deck – Actions Taken to Date
Gilly Griffin, Canadian Council for Animal Care ; Jonathan Kimmelman, McGill Univ

Russell and Burch Revisited: Reconciling “Reproducibility” with “Replacement, Reduction, and Refinement”
Michael Festing, Independent Consultant ; Stephen Latham, Yale Univ

Can Research Integrity be Incentivized?
Brian Martinson, HealthPartners Institute for Education & Research ; Elizabeth Marincola, PLoS

Reproducibility Challenges in the Future of Animal Models
Roger Reeves, Johns Hopkins Univ ; Jeffrey Rogers, Baylor College of Medicine ; Monte Westerfield, Univ of Oregon

Improving the Reliability of Published Results
Gaylen Edwards, American Physiological Society ; Elizabeth Marincola, PLoS ; Victoria Stodden, Columbia Univ

IOs, Vets, and IACUCs – Making Internal Regulators Partners in Reform
Kathryn Bayne, AAALAC International ; Stuart Zola, Emory Univ ; Jerry Collins, Yale Univ

An Ounce of Prevention is Worth a Billion of Cure: Proactive Planning in the Preclinical Research Arena
John P. A. Ioannidis, Stanford Prevention Research Center ; Paul Braunschweiger, CITI Program ; Ghislaine Poirier, GlaxoSmithKline

Summing Up: Lessons Learned, Major Themes and Potential Actions for Moving Forward
Kent Lloyd, Univ of California, Davis

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The second workshop, to be held September 3-4, 2014, will examine issues relating to transportation of laboratory animals.

Related blog post:  National Academies Launches New Roundtable on Laboratory Animal Science and Welfare

American College of Animal Welfare (ACAW)

April 21st, 2014 by Mary Wood

clip_image001Animal Welfare Short Course
May 15-17, 2014
North Carolina State University
College of Veterinary Medicine
Raleigh, North Carolina

Veterinarians interested in gaining specialized knowledge regarding animal welfare assessments, contemporary animal welfare issues, and the veterinarian’s role in animal welfare should plan to attend, including veterinarians interesting in preparing for board certification by the American College of Animal Welfare.

Registration, the course agenda, speaker list, and additional information

ILAR Roundtable

March 21st, 2014 by Mary Wood

National Academies Launches New Roundtable on Laboratory Animal Science and Welfare

ilarcollage-newphotos-new2Bridging Communities, Fostering Communications

The National Academies’ Institute for Laboratory Animal Research (ILAR) has launched the ILAR Roundtable to stimulate dialogue and provide new pathways to promote the responsible use of animals in science.  The ILAR Roundtable provides a forum for researchers and animal care givers from government, industry, and academia to discuss animal welfare in research, and an opportunity to discuss topics ranging from laboratory animal care to experimental design to regulatory issues.

Roundtable Members include faculty members from UC Davis:  Dr. Kent Lloyd and Dr. John Wingfield

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Roundtable Workshops

The Roundtable is a balanced and civil forum to stimulate dialogue and collaboration, to help build trust and transparency among stakeholders, and to provide a new medium to promote the responsible use of animals in science.

Workshop #1:  Reproducibility Issues in Research with Animals and Animal Models: A Workshop, June 4-5, 2014
The National Research Council has appointed a committee of experts to organize and conduct a public workshop to discuss fundamental aspects of experimental design of research using animals and animal models, aimed at improving reproducibility.

Workshop #2: Transportation of Laboratory Animals,  September 3-4, 2014
Speakers and agenda to be announced

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ILAR publications focus on laboratory animals, including :

Guide for the care and use of laboratory animals, 8th edition

Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary

International Animal Research Regulations: Impact on Neuroscience Research: Workshop Summary

Recognition and Alleviation of Pain in Laboratory Animals

Recognition and Alleviation of Distress in Laboratory Animals

Guidelines for the Humane Transportation of Research Animals

Social Housing for Lab Animals – symposium presentations

March 7th, 2014 by Mary Wood

Selected presentations from the Symposium on Social Housing of Laboratory Animals are available, hosted by AWIC, Animal Welfare Information Center, a service of the National Agricultural LibraryThe symposium was co-hosted by NIH, USDA, OLAW, The Enrichment Record, and the Johns Hopkins Center for Alternatives to Animal Testing (CAAT) on August 22-23, 2013 and held at the National Institutes of Health (NIH) Natcher Center in Bethesda, Maryland.

social

Presentations include:

Socialization: Behavioral Intervention and Temperament Testing
Kristine Coleman, Oregon Health & Science University

Socialization of Nonhuman Primate Groups
Steven Schapiro, The University of Texas MD Anderson Cancer Center

Federal Oversight and Peer-Review Perspectives on Social Housing: Representatives from AAALAC, USDA, and OLAW
Carol Clarke, USDA, APHIS; Brent Morse, NIH, OLAW; and Kathryn Bayne, AAALAC

Pigs: Social Housing
Candace Croney, Purdue University

Rabbits: Social Housing
Karen Froberg, Bio-Serv

A Historical Perspective on Social Housing
Kathryn Bayne, AAALAC

Reporting animal studies: ARRIVE news

January 24th, 2014 by Mary Wood
NC3Rs-ARRIVE-guidelines-Z-card-300x263
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Editorial
Open Science and Report Animal Studies: Who’s Accountable?
Jonathan A. Eisen, Emma Ganley, Catriona J. MacCallum
(2014) PLoS Biol 12(1): e1001757. doi:10.1371/journal.pbio.1001757
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Perspective
Two Years Later: Journals Are Not Yet Enforcing the ARRIVE Guidelines on Reporting Standards for Pre-Clinical Animal Studies
Baker D, Lidster K, Sottomayor A, Amor S
(2014) PLoS Biol 12(1): e1001756. doi:10.1371/journal.pbio.1001756
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from NC3Rs Blog
…The ARRIVE (Animal Research: Reporting of In Vivo Research) guidelines, published in 2010 in PLOS Biology, were developed … to improve the reporting of animal research to ensure maximum benefit and to minimise unnecessary animal studies…

Research published this week in PLOS Biology shows experimental flaws and inadequacies in the reporting of animal research in the field of neuroimmunology …

PLOS Biology published an editorial to coincide with the original article
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PLOS journals are requesting authors to use the ARRIVE guidelines checklist when submitting relevant manuscripts to ensure reporting of animal research meets minimum standards. In April 2013, Nature journals adopted a similar approach and introduced editorial measures to improve transparency of research which includes a checklist incorporating elements of the ARRIVE guidelines…
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Perspective
Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research
Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG
(2010) PLoS Biol 8(6): e1000412. doi:10.1371/journal.pbio.1000412